In-Vivo MS FX PRO
The MS FX PRO is the most powerful and versatile small animal imaging system for preclinical research. With multispectral fluorescence, luminescence, radioisotopic and high resolution X-ray imaging in one system, it brings the broadest range of imaging applications - from protein blots to complex, longitudinal studies of disease states in vivo - to your lab. Whether you need to develop fluorescent probes; track NIR fluorescent nanoparticles, peptides or proteins; quantify changes in localization and tumor burden; screen radioisotopic probes in multiple animals; study changes in bone density or perform ex vivo validation, the MS FX PRO drives your research to new levels of excellence.
NEW! Fast f/0.95 fixed lens option is ideal for laboratories whose research focuses on luminescence applications in vivo or ex vivo.
NEW! The MS FX PRO now comes standard with a high speed X-ray head providing X-ray images for co-registration in just 3 seconds.
- The In-Vivo MS FX PRO now offers a choice of 10X zoom or a NEW fast f/0.95 lens for luminescence or high sensitivity radioisotopic applications
- NEW high speed X-ray head for rapid 3 second small animal X-ray images
- 3.3 X geometric magnification stage standard for very high resolution X-ray imaging
- Unmatched versatility - 4 modalities (fluorescence, luminescence, radioisotopic and radiographic) in one system
- Excitation-based spectral unmixing capability is standard – not a costly add-on
- Exceptionally sharp, quantifiable X-ray images > 25 lp/mm with zoom lens system
- Luminescence sensitivity
- Accurate scientific units (XD, pW/mm2, photons/sec/mm2, g/cm3 (long bones)
- Patented wide angle emission filters - (interchangeable)
- Up to a large 200 mm FOV with zoom lense or 138 mm FOV with fixed lens option
- Upgrade path from existing systems
- Optional Multimodal Animal Rotation System (MARS) for 360 degree imaging
- Pair with Albira PET/SPECT/CT for seven small animal imaging modalities in just 2 powerful, compact instruments
Use the In-Vivo MS FX PRO for making fundamental biological discoveries and preclinical validation of therapeutics and biomarkers. Image changes in signaling cascades in live animals over time to discover how genetics, small molecules, and therapeutics affect these pathways. Validate and discover new molecular imaging probes and pre-clinical biomarkers—ideal for multi-functional imaging agents including nanoparticles, peptides, antibodies and more.
Specific applications include:
- Oncology
- Neuroscience
- Bone disease
- Cardiology
- Metabolic disease
- Autoimmune disorders
- Infectious disease
- Inflammation
and more.
NEW fast f/0.95 lens option
Ideal for luminescent and radioisotopic imaging capabilities
NEW high speed X-ray head
For rapid 3 second small animal X-ray images
3.3 X geometric magnification stage
Standard for very high resolution X-ray imaging
Molecular Imaging software
Carestream MI software combines powerful, easy to use image capture and visualization with simple, automated analysis and reporting tools. The intuitive user interface streamlines workflow, and provides a unified platform for managing all in vivo and in vitro images.
MARS Multimodal Animal Rotation System (optional)
MARS automatically rotates a mouse to the desired angle or angles to capture all relevant molecular and anatomical information. MARS rotation software enables automatic co-registration and visualization of multimodal and multispectral data sets from all acquired angles. Increase sensitivity by quantifying the perfect image or simply export an entire rotation movie.
Automated Animal Heater (standard)
Under anesthesia the body temperature of rodents can drop, endangering their health and your data. Our new animal heater bathes your animals a continuous flow of warm air to maintain their body temperature during your most critical experiments.
400W Illuminator (standard)
The new broad spectrum, ultra bright 400W Illuminator is designed specifically for customers with the most demanding fluorescence imaging applications. Xenon illumination provides broad spectrum excitation throughout the visible and NIR spectrum to provide you the greatest choice of fluorophores for your in vivo and in vitro experiments.
Automated Small Animal Anesthesia System (optional)
Automated gas anesthesia system regulates flow to protect animals and researchers from overexposure.
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Camera
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CCD
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Monochrome interlined CCD
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Pixel Density
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2048 x 2048 pixels
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Cooling
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-29°C absolute
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Lens
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Computer Controlled 10X zoom, 20 - 200mm, ƒ2.5, fast f/0.95 lens option
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Illumination
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Source
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400 W Xenon
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Fluorescence
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Automated 29-position selectable multiwavelength epi-illumination, 410 - 760 nm – includes 28 excitation filters and 400 W Xenon illumination source
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White Light
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White light epi-illumination and white light transillumination
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Emission Filters
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Automated selectable wide angle filters, 535 - 830 nm – includes 6 emission filters
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Performance
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Field of View
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Zoom Lens - 2 x 2 cm to 20 x 20 cm, continuous automated zoom
Fixed lens - 13.8 cm x 13.8 cm
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Image Resolution
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Zoom lens - 10 um\pixel (max)
Fixed lens: 67 um\pixel
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Data Acquisition
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16-bit single capture
n-bit data acquisition
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Binning
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1x2, 2x2, 1x4, 2x4, 4x4, 1x8, 2x8, 4x8, 8x8, 16x16
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Read Noise
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<7-rms (nominal)
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Dynamic Range
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>4 OD
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Dark Current Noise
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<= 5 x 10-5 e/s/pixel
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Detection Modes
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Luminescence
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Multiwavelength Fluorescence
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Radioisotopic
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X-ray
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Exposure Modes
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Single Capture
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Multiple Capture
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Progressive Exposure
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Time Lapse Exposure
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Computer Interface
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Ethernet
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Operating Systems
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WINDOWS XP , WINDOWS 7, MACINTOSH OS X |
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Digital X-ray
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Energy Range
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20-45 kVp
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Resolution Contact
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Zoom lens - 25 lp\mm (nominal)
Fixed lens - 19 lp\mm (using magnification)
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Maximum Current
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500uA
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Spot Size
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<60 U
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Target Material
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Tungsten
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Window Filtration
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Beryllium
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Cone of Illumination
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>33 degrees
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Field of Illumination
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20 X 20 cm
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Instrument
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Approximate Dimensions (in)
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(in) 41 x 19 x 38 (cm) 104 x 48 x 97 (l x w x h)
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Approximate Net Weight
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313 lbs, 142 kg
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The Carestream Molecular Imaging In-Vivo MS FX PRO system is one of the most versatile in vivo optical imaging systems allowing for multimodal X-ray, multispectral fluorescence, luminescence and radioisotopic in vivo imaging. The system is complemented by integrated analysis software. Accessories like the geometric magnification stage, bone density software, and multimodal animal rotation system provide for significant enhancements in imaging capabilities and analysis.
Learn More about the In-Vivo MS FX PRO End-User Workshop