In-Vivo Xtreme Preclinical Small Animal Imaging System

Extremely Versatile
One system, four modalities

Fluorescence
Luminescence
Radioisotopic
Radiographic

Choice of front-illuminated 16 MP or back- illuminated 4 MP camera
Animal transport to Albira PET/SPECT/CT and MRI

High Resolution X-ray
True microfocus X-ray head
Energy optimized for small animal imaging
Five different aluminum filtration options
Ultra-thin, uniform radiographic phosphor screen

Animal Management
Easily image up to five mice at a time
Automated switching between modalities – the animal never moves
Light-tight ports for catheters and temperature monitoring

Ultra Sensitive Imaging System
High speed lens f/1.1
Largest CCD sensor in its class
Exclusive wide angle emission filters eliminate imaging artifacts
Spectral deconvolution removes autofluorescence

Powerful Light Source
Broad spectrum 400W Xenon illumination
Fluorescent imaging from the visible to near IR

Camera and Lens
Detector Type	1) Interline front-illuminated (FI) 16 MP CCD detector 2) Back-thinned, back-illuminated (BI) 4MP CCD detector
CCD Pixel	1) FI 16MP: 4872 x 3248 2) BI 4MP: 2048 x 2048
CCD Size	1) FI 16MP: 36 x 24 mm 2) BI 4MP: 27.6 x 27.6 mm
Size of Pixel on Sensor	1) FI 16MP: 7.4 μ m 2) BI 4MP: 13.5 μ m
Read Noise	1) FI 16MP: 8 e- 2) BI 4MP: 3 e-
FOV	1) FI 16MP: 10 x 6.6 cm to 20 x 13 cm 2) BI 4MP: 7.2 x 7.2 cm to 20 x 20 cm
Lens	f/1.1 – f/16, 58 mm lens, fixed
Luminescence Sensitivity	1) FI 16MP: <112 photons/sec/cm2/sr 2) BI 4MP: <50 photons/sec/cm2/sr
Fluorescence Specifications
Light Source	400WXenon illuminator
Excitation Filters	28
Excitation Wavelength Range	410 nm – 760 nm
Emission Filters	6 filters, 8 position wheel
Emission Filter Wavelength Range	535 nm – 830 nm
Patented High-Sensitivity Wide Angle Filters	Yes
X-ray Specifications
Maximum Resolution (lp/mm)	1) FI 16MP: > 25 lp/mm 2) BI 4MP: > 18 lp/mm
X-ray Spot Size (Nominal μm)	<60 μm
Energy Range (kVp)	20-45 kVp
Max Current (μA)	500 μA
Filters	0.1 mm, 0.2 mm, 0.4 mm, 0.8 mm, or no filter
Physical Specifications
Footprint (W x D x H cm)	72 x 84 x 183 cm
Imaging Modalities	Fluorescence, luminescence, radioisotopic, and radiographic
Catheter Ports	Yes
Compatible with most commercial gas anesthesia	Yes
Animal Warming	Warm air 20°C – 40°C
Computer Supplied	Yes

In-Vivo Xtreme’s sensitivity and versatility make it the ideal tool for a broad range of preclinical imaging applications, including:

Tumor and stem cell tracking
Luminescence imaging of inflammation
Optical imaging of PET probes with Cherenkov radiation
Tracking and validating single or multimodal nanoparticles
Imaging and validating new probes and biomarkers
Non-invasively image changes in signaling cascades
Discover how genetics, small molecules and therapeutics affect biochemical pathways
Quantify changes in bone and soft tissue phenotype
High throughput pharmacodynamic studies

...and much much more!

The Carestream Molecular Imaging In-Vivo Xtreme system is one of the most versatile in vivo optical imaging systems allowing for multimodal X-ray, multispectral fluorescence, luminescence and radioisotopic in vivo imaging. The system is complemented by integrated analysis software. Accessories like the geometric magnification stage, bone density software, and multimodal animal rotation system provide for significant enhancements in imaging capabilities and analysis.

Learn More about the In-Vivo Xtreme End-User Workshop

NEW! In-Vivo Xtreme

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